Research topic
Mechanosensitive channel implicated in the NLGN3-CSPG4 pathway in tested models.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
Neuronal activity feeds glioma growthInterpret activity-dependent growth and conditional NLGN3 dependence.
Supports: PIEZO1
Nat Neurosci · 2026
Kim YS, Gillespie SM, Geraghty AC, et al., Trotter J, Monje M
Why this matters: Connects binding, membrane tension, and electrical/growth responses while implicating normal OPC biology.
DOI: 10.1038/s41593-026-02397-8