Research topic
Engineered T-cell therapies with promising early activity and serious toxicity; controlled evaluation remains necessary.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
From cancer neuroscience to new therapiesDistinguish early GD2 CAR T activity from established clinical efficacy.
Supports: CAR T-cell therapy
Nature · 2025
Monje M, Mahdi J, Majzner R, et al., Mackall C
Why this matters: Reports small phase-one clinical activity and serious toxicity; not established cure or comparative efficacy.
DOI: 10.1038/s41586-024-08171-9
Nat Med · 2018
Mount CW, Majzner RG, Sundaresh S, et al., Mackall CL, Monje M
Why this matters: Provides preclinical rationale, with animal effects separate from clinical outcomes.
DOI: 10.1038/s41591-018-0006-x
Cell · 2025
Geraghty AC, Acosta-Alvarez L, Rotiroti MC, et al., Monje M
Why this matters: Examines mouse neural effects; this is not evidence of human cognitive rescue.
DOI: 10.1016/j.cell.2025.03.041