Research topic
Muscarinic signaling promotes growth in tested DMG models; functional cholinergic synapses remain unproven.
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Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
Cancer cells join neural circuitsSeparate functional synaptic evidence from cell identity.
Supports: Cholinergic signaling
Cell · 2025
Drexler R, Drinnenberg A, Gavish A, et al., Deisseroth K, Monje M
Why this matters: Supports muscarinic growth signaling; published abstract and preprint details were checked, not proof of cholinergic synapses.
DOI: 10.1016/j.cell.2025.05.031