Research topic
A pediatric-type H3K27-altered midline tumor entity that can occur in the pons, thalamus, or spinal cord.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
Diffuse midline glioma: when development and cancer intersectRelate diffuse midline glioma to developmental cell states.
Supports: Diffuse midline glioma
Nature · 2025
Barron T, Yalçın B, Su M, et al., Kaila K, Monje M
Why this matters: Shows that chloride regulation can make GABA depolarizing in DMG models.
DOI: 10.1038/s41586-024-08579-3
Nat Med · 2026
Barron T, Drexler R, Mochizuki A, et al., Koschmann C, Monje M
Why this matters: Combines preclinical benefits and retrospective associations; prospective clinical efficacy remains to be tested.
DOI: 10.1038/s41591-026-04646-6