Research topic
Treatment-related glial and myelin effects studied preclinically must be distinguished from human cognitive rescue.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
From cancer neuroscience to new therapiesDistinguish early GD2 CAR T activity from established clinical efficacy.
Supports: Cancer-treatment-related cognitive impairment
Cell · 2019
Gibson EM, Nagaraja S, Ocampo A, et al., Monje M
Why this matters: Studies treatment-related glial effects in a preclinical setting.
DOI: 10.1016/j.cell.2018.10.049
Cell · 2025
Geraghty AC, Acosta-Alvarez L, Rotiroti MC, et al., Monje M
Why this matters: Examines mouse neural effects; this is not evidence of human cognitive rescue.
DOI: 10.1016/j.cell.2025.03.041