Research topic
DMG chloride regulation can make GABA depolarizing; effects differ across cells and tumor types.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
Cancer cells join neural circuitsSeparate functional synaptic evidence from cell identity.
Supports: GABAergic signaling
Nature · 2025
Barron T, Yalçın B, Su M, et al., Kaila K, Monje M
Why this matters: Shows that chloride regulation can make GABA depolarizing in DMG models.
DOI: 10.1038/s41586-024-08579-3
Nat Med · 2026
Barron T, Drexler R, Mochizuki A, et al., Koschmann C, Monje M
Why this matters: Combines preclinical benefits and retrospective associations; prospective clinical efficacy remains to be tested.
DOI: 10.1038/s41591-026-04646-6