Research topic
Activity-regulated growth signaling and model-specific dependencies, with other factors and escape mechanisms relevant.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
Neuronal activity feeds glioma growthInterpret activity-dependent growth and conditional NLGN3 dependence.
Supports: Neuroligin-3
Cell · 2015
Venkatesh HS, Johung TB, Caretti V, et al., Monje M
Why this matters: Links controlled neuronal activity and secreted growth factors in mouse glioma models.
DOI: 10.1016/j.cell.2015.04.012
Nature · 2017
Venkatesh HS, Tam LT, Woo PJ, et al., Monje M
Why this matters: Tests NLGN3 dependency and shedding, with escape and model scope relevant.
DOI: 10.1038/nature24014
Nat Neurosci · 2026
Kim YS, Gillespie SM, Geraghty AC, et al., Trotter J, Monje M
Why this matters: Connects binding, membrane tension, and electrical/growth responses while implicating normal OPC biology.
DOI: 10.1038/s41593-026-02397-8