Research topic
Versioned frameworks distinguish functional capabilities, enabling characteristics, emerging hallmarks, and proposed new dimensions.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
The Hallmarks of Cancer, Part I: how tumors learn to growDistinguish hallmark capabilities from individual genes.
Supports: Hallmarks of Cancer
Cancer as a Neural Circuit Disease
The Hallmarks of Cancer, Part II: adaptation, invasion, and evolutionRelate invasion, metabolic change, immune escape, and plasticity to cancer behavior.
Supports: Hallmarks of Cancer
Cancer Cell · 2023
Hanahan D, Monje M
Why this matters: A perspective placing neural components in the tumor ecosystem, not declaring a new official hallmark.
DOI: 10.1016/j.ccell.2023.02.012
Cancer Discov · 2022
Hanahan D
Why this matters: Distinguishes eight core capabilities from proposed plasticity and other new dimensions in the 2022 framework.
DOI: 10.1158/2159-8290.CD-21-1059