Research topic
Histone/chromatin changes including PRC2 inhibition in H3K27M models; the entity is broader than a single mutation.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
Diffuse midline glioma: when development and cancer intersectRelate diffuse midline glioma to developmental cell states.
Supports: H3K27 alteration
Science · 2018
Filbin MG, Tirosh I, Hovestadt V, et al
Why this matters: Characterizes developmental cell states without proving a universal cell of origin.
DOI: 10.1126/science.aao4750