Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Systems medicine
Physiological circuit models connecting useful design to possible disease fragilities.
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Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Design Principles of Life, Disease, and Aging
Systems medicine: when a useful circuit creates a diseaseRelate physiological function to circuit design.
Supports: Systems medicine
Important papers
Immunity · 2020
Endocrine autoimmune disease as a fragility of immune surveillance against hypersecreting mutants
Y. Korem Kohanim, A. Tendler, A. Mayo, N. Friedman & U. Alon
Why this matters: Develops a bounded mutant-surveillance hypothesis rather than a universal autoimmune cause.
DOI: 10.1016/j.immuni.2020.04.022