Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Gompertz law
An approximate adult population pattern of rising mortality, with age-range and population limits.
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Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Design Principles of Life, Disease, and Aging
Systems aging: why does risk rise so sharply with age?Interpret approximate population mortality patterns.
Supports: Gompertz law
Important papers
Nature Communications · 2019
Senescent cell turnover slows with age providing an explanation for the Gompertz law
O. Karin, A. Agrawal, Z. Porat, V. Krizhanovsky & U. Alon
Why this matters: Combines mouse clearance observations with a quantitative saturated-removal model.
DOI: 10.1038/s41467-019-13192-4