Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Feedback control
Regulatory feedback can create fast responses, robustness, or alternative stable states under specified conditions.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Labs and groups studying related work
Professors
Lessons to understand this topic
Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Design Principles of Life, Disease, and Aging
Network motifs: the recurring circuits of biologyCompare motif counts with a degree-preserving randomized null model.
Supports: Feedback control
Design Principles of Life, Disease, and Aging
Immune circuits, inflammation, and fibrosis as dynamical systemsInterpret alternative stable states and history dependence in fibrosis models.
Supports: Feedback control
Important papers
J. Mol. Biol · 2002
Negative autoregulation speeds the response times of transcription networks
N. Rosenfeld, M. B. Elowitz & U. Alon
Why this matters: Tests a specific response-time advantage of negative autoregulation.
DOI: 10.1016/s0022-2836(02)00994-4