Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Bistability
Alternative stable states can generate threshold and history-dependent responses.
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Core background
Design Principles of Life, Disease, and Aging
How do you discover a design principle?Interpret production-minus-removal ordinary differential equations.
Supports: Bistability
Design Principles of Life, Disease, and Aging
Immune circuits, inflammation, and fibrosis as dynamical systemsInterpret alternative stable states and history dependence in fibrosis models.
Supports: Bistability
Important papers
iScience · 2020
Principles of cell circuits for tissue repair and fibrosis
M. Adler et al
Why this matters: Models alternative healing and fibrotic steady states.
DOI: 10.1016/j.isci.2020.100841