Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Feed-forward loops
Coherent and incoherent circuits whose behavior depends on signs, gates, delays, and parameters.
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Core background
Design Principles of Life, Disease, and Aging
Network motifs: the recurring circuits of biologyCompare motif counts with a degree-preserving randomized null model.
Supports: Feed-forward loops
Important papers
J. Mol. Biol · 2003
The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks
S. Mangan, A. Zaslaver & U. Alon
Why this matters: Tests persistence detection and sign-sensitive delay in a specified coherent loop.
DOI: 10.1016/j.jmb.2003.09.049