Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Fibrosis
Macrophage and myofibroblast circuit models can support healing, hot fibrosis, or cold fibrosis.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
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Lessons to understand this topic
Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Design Principles of Life, Disease, and Aging
Immune circuits, inflammation, and fibrosis as dynamical systemsInterpret alternative stable states and history dependence in fibrosis models.
Supports: Fibrosis
Important papers
iScience · 2020
Principles of cell circuits for tissue repair and fibrosis
M. Adler et al
Why this matters: Models alternative healing and fibrotic steady states.
DOI: 10.1016/j.isci.2020.100841