Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Network motifs
Patterns enriched against an appropriate randomized network comparison; enrichment alone does not establish function.
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Core background
Design Principles of Life, Disease, and Aging
Network motifs: the recurring circuits of biologyCompare motif counts with a degree-preserving randomized null model.
Supports: Network motifs
Important papers
Science · 2002
Network motifs: simple building blocks of complex networks
R. Milo, S. Shen-Orr, S. Itzkovitz, N. Kashtan, D. Chklovskii & U. Alon
Why this matters: Establishes statistical motif enrichment using randomized comparisons.
DOI: 10.1126/science.298.5594.824
Nature Genetics · 2002
Network motifs in the transcriptional regulation network of Escherichia coli
S. S. Shen-Orr, R. Milo, S. Mangan & U. Alon
Why this matters: Links recurring regulatory circuits to a biological transcription network.
DOI: 10.1038/ng881
Nature Reviews Genetics · 2007
Network motifs: theory and experimental approaches
U. Alon
Why this matters: Connects statistical patterns, dynamical models, and experiments in a review.
DOI: 10.1038/nrg2102