Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Systems aging
Quantitative aging models connect damage production, finite removal capacity, and population patterns.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
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Lessons to understand this topic
Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Design Principles of Life, Disease, and Aging
Systems aging: why does risk rise so sharply with age?Interpret approximate population mortality patterns.
Supports: Systems aging
Design Principles of Life, Disease, and Aging
Where the Alon Lab is going now: tissues, aging, and predictive medicineExplain model-based inference of tissue dynamics from spatial snapshots.
Supports: Systems aging
Important papers
Nature Communications · 2019
Senescent cell turnover slows with age providing an explanation for the Gompertz law
O. Karin, A. Agrawal, Z. Porat, V. Krizhanovsky & U. Alon
Why this matters: Combines mouse clearance observations with a quantitative saturated-removal model.
DOI: 10.1038/s41467-019-13192-4
Aging Cell · 2021
Senescent cells and the incidence of age-related diseases
I. Katzir et al
Why this matters: Relates damage thresholds to age-related disease incidence within a model.
DOI: 10.1111/acel.13314
Science · 2026
Heritability of intrinsic human life span is about 50% when confounding factors are addressed
B. Shenhar, G. Pridham, T. L. De Oliveira, N. Raz, Y. Yang, J. Deelen, S. Hägg & U. Alon
Why this matters: Estimates population heritability after correcting extrinsic mortality; not individual genetic destiny.
DOI: 10.1126/science.adz1187