Research topic
Expression profiles identify cell states; tissue dissociation loses spatial position.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
9 lessons · ~50 minutes
Explore the labResearch develops biological measurement tools and applies them to single-cell genomics, genomic diagnostics, microbial ecology, and quantitative biological analysis. This independent primer distinguishes historical lab contributions, collaborative and consortium results, current research, and clinical screening from diagnosis.
6 lessons · ~29 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Cancer as a Neural Circuit Disease
Diffuse midline glioma: when development and cancer intersectRelate diffuse midline glioma to developmental cell states.
Supports: Single-cell RNA sequencing
Measuring Life: From Single Cells to Liquid Biopsies
Single-cell genomics: why one cell at a time mattersDistinguish genome, transcriptome and bulk versus single-cell information.
Supports: Single-cell RNA sequencing
Cancer as a Neural Circuit Disease
How do you study communication between neurons and cancer cells?Match experimental methods to structure, activity, and cell-state questions.
Supports: Single-cell RNA sequencing
Science · 2018
Filbin MG, Tirosh I, Hovestadt V, et al
Why this matters: Characterizes developmental cell states without proving a universal cell of origin.
DOI: 10.1126/science.aao4750
Nature · 2014
Treutlein B, Brownfield DG, Wu AR, et al., Krasnow MA, Quake SR
Why this matters: COLLABORATIVE PRIMARY RESULT: 198 cells across four developmental stages of mouse lung; not every human lung state.
DOI: 10.1038/nature13173
PNAS · 2015
Darmanis S, Sloan SA, Zhang Y, et al., Barres BA, Quake SR
Why this matters: COLLABORATIVE PRIMARY RESULT: 466 adult and fetal human brain cells reveal transcriptomic diversity.
DOI: 10.1073/pnas.1507125112