Research topic
Cell-free DNA in biological measurement: Cell-free DNA and liquid biopsy, Molecular counting in prenatal and transplant monitoring. Interpretation retains sampling, model, and validation limits.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research develops biological measurement tools and applies them to single-cell genomics, genomic diagnostics, microbial ecology, and quantitative biological analysis. This independent primer distinguishes historical lab contributions, collaborative and consortium results, current research, and clinical screening from diagnosis.
6 lessons · ~29 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Measuring Life: From Single Cells to Liquid Biopsies
Liquid biopsy: reading the body's molecular debrisInterpret fragmented extracellular DNA as a molecular mixture.
Supports: Cell-free DNA
PNAS · 2015
De Vlaminck I, Martin L, Kertesz M, et al., Khush KK, Quake SR
Why this matters: QUAKE-LAB PRIMARY RESULT: lung-transplant monitoring of rejection and infection; DNA detection alone does not prove viable organisms caused disease.
DOI: 10.1073/pnas.1517494112