Research topic
Deconvolution in biological measurement: Cell-free RNA and tissue-of-origin inference, Reference atlases, mixture models, and deconvolution. Interpretation retains sampling, model, and validation limits.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research develops biological measurement tools and applies them to single-cell genomics, genomic diagnostics, microbial ecology, and quantitative biological analysis. This independent primer distinguishes historical lab contributions, collaborative and consortium results, current research, and clinical screening from diagnosis.
6 lessons · ~29 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Measuring Life: From Single Cells to Liquid Biopsies
Cell-free RNA: can a blood sample tell us what tissues are doing?Explain why cfRNA can carry expression information but source inference needs assumptions.
Supports: Deconvolution
Nat Biotechnol · 2022
Vorperian SK, Moufarrej MN, Tabula Sapiens Consortium, Quake SR
Why this matters: CONSORTIUM / COLLABORATIVE PRIMARY RESULT: Tabula Sapiens reference-based nu-SVR validated on bulk tissues. Similar and missing signatures limit identifiability.
DOI: 10.1038/s41587-021-01188-9