Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Physiological circuits
Coupled hormone and cell-population circuits with fast and slow variables.
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Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Design Principles of Life, Disease, and Aging
Systems medicine: when a useful circuit creates a diseaseRelate physiological function to circuit design.
Supports: Physiological circuits
Design Principles of Life, Disease, and Aging
Hormone circuits: robustness, diabetes, and slow physiological memoryExplain dynamical compensation in glucose-insulin models.
Supports: Physiological circuits
Important papers
Mol. Syst. Biol · 2017
Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
O. Karin & U. Alon
Why this matters: Proposes a protective design with a potential glucotoxicity fragility.
DOI: 10.15252/msb.20177599