Karl Deisseroth Lab
Karl DeisserothControlling, mapping and modeling neural circuits across cell types, space and behavior.
9 lessons · ~48 minutes
Explore the labResearch topic
Optogenetics
Using genetically targeted light-sensitive proteins to control defined neurons.
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Labs and groups studying related work
Michelle Monje Lab
Michelle MonjeResearch at the intersection of neurodevelopment, glioma biology, neural activity, tumor microenvironment signaling, cancer neuroscience, and mechanism-guided therapies.
Cancer biologyCancer neuroscienceCancer-treatment-related cognitive impairmentCAR T-cell therapyCholinergic signaling
9 lessons · ~50 minutes
Explore the labProfessors
Lessons to understand this topic
Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Cancer as a Neural Circuit Disease
How do you study communication between neurons and cancer cells?Match experimental methods to structure, activity, and cell-state questions.
Supports: Optogenetics
Controlling, Mapping, and Modeling Neural Circuits
Optogenetics: controlling defined neurons with lightTrace how a light-sensitive protein expressed in selected neurons changes their activity.
Supports: Optogenetics
Important papers
Nat Neurosci 8:1263–1268 · 2005
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K
Why this matters: Introduces genetically targeted optical control of neural activity.
DOI: 10.1038/nn1525