Karl Deisseroth Lab
Karl DeisserothControlling, mapping and modeling neural circuits across cell types, space and behavior.
9 lessons · ~48 minutes
Explore the labResearch topic
Cortical organoids
Human-derived developmental models with explicit limitations.
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Core background
Controlling, Mapping, and Modeling Neural Circuits
Human brain organoids: what can they model?Trace how cortical organoids are derived from pluripotent stem cells.
Supports: Cortical organoids
Important papers
Nature 610:319–326 · 2022
Maturation and circuit integration of transplanted human cortical organoids
Revah O, Gore F, Kelley KW, et al., Deisseroth K, Pașca SP
Why this matters: Studies maturation and integration of human cortical organoids in a host model; collaborative work.
DOI: 10.1038/s41586-022-05277-w
Nature · 2026
Developmental xenocortication using human-derived organoids in mice
Kaganovsky K, Kelley KW, Gschwind T, Harary PM, et al., Deisseroth K, Pașca SP
Why this matters: A multi-group Stanford collaboration led by the Pașca lab, with Deisseroth among contributors; developmental models do not establish clinical efficacy.
DOI: 10.1038/s41586-026-11032-2