Karl Deisseroth Lab
Karl DeisserothControlling, mapping and modeling neural circuits across cell types, space and behavior.
9 lessons · ~48 minutes
Explore the labResearch topic
Spatial transcriptomics
Locating molecularly defined cells and gene expression within tissue.
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Core background
Controlling, Mapping, and Modeling Neural Circuits
STARmap: where are the molecularly defined cells?Explain why spatial transcriptomics combines molecular identity with tissue location.
Supports: Spatial transcriptomics
Decode Life: AI & Computational Biology
Gene-expression matricesAn expression matrix can place genes in rows and samples in columns, or the reverse.
Supports: Spatial transcriptomics
Important papers
Science 361:eaat5691 · 2018
Three-dimensional intact-tissue sequencing of single-cell transcriptional states
Wang X, Allen WE, Wright MA, et al., Deisseroth K
Why this matters: Links cell transcriptional states to positions in intact tissue.
DOI: 10.1126/science.aat5691