Karl Deisseroth Lab
Karl DeisserothControlling, mapping and modeling neural circuits across cell types, space and behavior.
9 lessons · ~48 minutes
Explore the labResearch topic
Tissue clearing
Making fixed tissue optically accessible for structural and molecular study.
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Core background
Controlling, Mapping, and Modeling Neural Circuits
CLARITY: making an intact brain transparentExplain how hydrogel stabilization and lipid removal make fixed tissue optically accessible.
Supports: Tissue clearing
Important papers
Nature 497:332–337 · 2013
Structural and molecular interrogation of intact biological systems
Chung K, Wallace J, Kim S-Y, et al., Deisseroth K
Why this matters: Establishes intact structural and molecular mapping through tissue clearing.
DOI: 10.1038/nature12107