Uri Alon Lab
Uri AlonResearch seeking simple quantitative design principles that explain biological circuits, physiology, disease, tissue dynamics, and aging.
9 lessons · ~48 minutes
Explore the labResearch topic
Senescence
Senescent cells are a leading candidate damage variable in tested saturated-removal models.
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Lessons to understand this topic
Recommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Core background
Design Principles of Life, Disease, and Aging
Systems aging: why does risk rise so sharply with age?Interpret approximate population mortality patterns.
Supports: Senescence
Important papers
Nature Communications · 2019
Senescent cell turnover slows with age providing an explanation for the Gompertz law
O. Karin, A. Agrawal, Z. Porat, V. Krizhanovsky & U. Alon
Why this matters: Combines mouse clearance observations with a quantitative saturated-removal model.
DOI: 10.1038/s41467-019-13192-4
Aging Cell · 2021
Senescent cells and the incidence of age-related diseases
I. Katzir et al
Why this matters: Relates damage thresholds to age-related disease incidence within a model.
DOI: 10.1111/acel.13314