Research topic
Involuntary difficulty initiating or continuing stepping, often during turns or task transitions.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Human Motor Control and Neuromodulation Laboratory: linking quantitative movement measurements with implanted subthalamic local field potentials and neuromodulation to understand Parkinson’s disease and develop personalized adaptive therapies.
5 lessons · ~27 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Decoding and Restoring Movement in Parkinson’s Disease
Parkinson’s disease: why does movement become difficult?Explain how dopamine loss disrupts distributed motor circuits without reducing Parkinson’s to dopamine alone.
Supports: Freezing of gait
Decoding and Restoring Movement in Parkinson’s Disease
AI, gait, and the future of personalized neuromodulationInterpret neural and wearable gait biomarkers within their measurement limits.
Supports: Freezing of gait
Brain Commun 7(4):fcaf266 · 2025
Wilkins KB, Petrucci MN, Lambert EF, Melbourne JA, Gala AS, Akella P, Parisi L, Cui C, Kehnemouyi YM, Hoffman SL, Aditham S, Diep C, Dorris HJ, Parker JE, Herron JA, Bronte-Stewart HM
Why this matters: Seven-participant investigational beta-burst-driven adaptive DBS study. Gait/freezing improved relative to stimulation OFF; group outcomes were comparable to continuous and random-adaptive stimulation, without universal superiority.
DOI: 10.1093/braincomms/fcaf266
J NeuroEng Rehabil 19:20 · 2022
O'Day J, Lee M, Seagers K, Hoffman S, Jih-Schiff A, Kidziński Ł, Delp S, Bronte-Stewart H
Why this matters: Evaluates wearable IMU locations for freezing detection and patient preference. Sensor placement and validation matter; detection alone is not evidence that treatment works.
DOI: 10.1186/s12984-022-00992-x