Research topic
Feedback-controlled stimulation that senses a signal, analyzes it and adjusts stimulation within defined bounds.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Human Motor Control and Neuromodulation Laboratory: linking quantitative movement measurements with implanted subthalamic local field potentials and neuromodulation to understand Parkinson’s disease and develop personalized adaptive therapies.
5 lessons · ~27 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Decoding and Restoring Movement in Parkinson’s Disease
From continuous DBS to a brain pacemaker that adaptsDescribe DBS as circuit modulation for selected patients, rather than a cure.
Supports: Adaptive DBS
Brain Commun 7(4):fcaf266 · 2025
Wilkins KB, Petrucci MN, Lambert EF, Melbourne JA, Gala AS, Akella P, Parisi L, Cui C, Kehnemouyi YM, Hoffman SL, Aditham S, Diep C, Dorris HJ, Parker JE, Herron JA, Bronte-Stewart HM
Why this matters: Seven-participant investigational beta-burst-driven adaptive DBS study. Gait/freezing improved relative to stimulation OFF; group outcomes were comparable to continuous and random-adaptive stimulation, without universal superiority.
DOI: 10.1093/braincomms/fcaf266
Brain Stimul 19(1):103028 (letter / case report) · 2026
Cui C, Choi JW, Karjagi S, Wilkins KB, Negi A, Bronte-Stewart HM
Why this matters: One-person at-home case report compares four-week adaptive and continuous DBS periods with neural sensing and daily digitography. Feasibility and individual patterns cannot establish population-level superiority.
DOI: 10.1016/j.brs.2026.103028