Research topic
Slowness and reduced amplitude of movement measured through clinical observation and quantitative kinematics.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Human Motor Control and Neuromodulation Laboratory: linking quantitative movement measurements with implanted subthalamic local field potentials and neuromodulation to understand Parkinson’s disease and develop personalized adaptive therapies.
5 lessons · ~27 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Decoding and Restoring Movement in Parkinson’s Disease
Parkinson’s disease: why does movement become difficult?Explain how dopamine loss disrupts distributed motor circuits without reducing Parkinson’s to dopamine alone.
Supports: Bradykinesia
Decoding and Restoring Movement in Parkinson’s Disease
How do you measure Parkinson’s movement and brain activity?Explain what continuous kinematic measurements add to observation.
Supports: Bradykinesia
Decoding and Restoring Movement in Parkinson’s Disease
Beta oscillations: a neural signature of impaired movementDistinguish beta power from threshold-defined burst duration.
Supports: Bradykinesia
Brain 144(2):473–486 (online December 2020) · 2021
Kehnemouyi YM, Wilkins KB, Anidi CM, Anderson RW, Afzal MF, et al., Bronte-Stewart HM
Why this matters: Relates stimulation-associated changes in beta bursts to improved bradykinesia. The primer uses abstract-level evidence; an association does not establish a sole cause.
DOI: 10.1093/brain/awaa394
Brain Commun 8(4):fcag245 · 2026
Seo G, Wilkins KB, Bronte-Stewart HM
Why this matters: In 16 participants, reduced pre-movement beta desynchronization was associated with worse motor performance across three tasks. This is distinct from beta power or burst duration.
DOI: 10.1093/braincomms/fcag245
Ann Neurol 93(5):1029–1039 · 2023
Wilkins KB, Kehnemouyi YM, Petrucci MN, Anderson RW, Parker JE, Trager MH, et al., Bronte-Stewart HM
Why this matters: Links bradykinesia and its progression with interhemispheric beta coherence over longitudinal observation. Coherence between signals differs from the power of a single signal; association is not causation.
DOI: 10.1002/ana.26605