Research topic
Gene regulation in physical biology: Can statistical mechanics predict gene expression?.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
Research using quantitative experiments, statistical mechanics, information theory, nonequilibrium physics, and large-scale biological measurements to discover predictive principles in gene regulation, biological fidelity, active matter, and viral ecology.
6 lessons · ~29 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Physical Biology: From Gene Regulation to Living Matter
Can statistical mechanics predict gene expression?Relate statistical weights to occupancy under stated assumptions.
Supports: Gene regulation
2005
Bintu L, Buchler NE, Garcia HG, Gerland U, Hwa T, Kondev J, Phillips R
Why this matters: PHILLIPS-LAB PRIMARY RESULT: published thermodynamic-model framework; a model is scoped by its assumptions.
2014
Jones DL, Brewster RC, Phillips R
Why this matters: PHILLIPS-LAB PRIMARY RESULT: published single-cell measurements test promoter-architecture models of variability.
2026
Yang Z, Rousseau RJ, Mahdavi SD, Garcia HG, Phillips R
Why this matters: PHILLIPS-LAB PRIMARY RESULT: published circuit dynamics connect molecular regulation to dynamical models.