Research topic
Allostery in physical biology: Can statistical mechanics predict gene expression?.
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Research using quantitative experiments, statistical mechanics, information theory, nonequilibrium physics, and large-scale biological measurements to discover predictive principles in gene regulation, biological fidelity, active matter, and viral ecology.
6 lessons · ~29 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Physical Biology: From Gene Regulation to Living Matter
Can statistical mechanics predict gene expression?Relate statistical weights to occupancy under stated assumptions.
Supports: Allostery
2018
Razo-Mejia M, Barnes SL, Belliveau NM, Chure G, Einav T, Lewis M, Phillips R
Why this matters: PHILLIPS-LAB PRIMARY RESULT: published induction measurements; ligand parameters fitted in one strain support predictions for others, not a wholly parameter-free fit.