Research topic
Biological fidelity in physical biology: Why does life spend energy to avoid mistakes?.
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Research using quantitative experiments, statistical mechanics, information theory, nonequilibrium physics, and large-scale biological measurements to discover predictive principles in gene regulation, biological fidelity, active matter, and viral ecology.
6 lessons · ~29 minutes
Explore the labRecommended through the concepts linked to this topic. Each lesson belongs to an existing learning series.
Physical Biology: From Gene Regulation to Living Matter
Why does life spend energy to avoid mistakes?Distinguish equilibrium discrimination from driven processes.
Supports: Biological fidelity
2026
Ravasio R, Husain K, Evans CG, Phillips R, Ribezzi-Crivellari M, Szostak JW, Murugan A
Why this matters: COLLABORATIVE PRIMARY RESULT: published Murugan-led models and selection simulations, with polymerase data consistent with the hypothesis; not universal proofreading.