Ngan F. Huang Lab
Ngan F. HuangCells, matrices and engineered environments for vascular and muscle regeneration.
6 lessons · ~46 minutes
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Ngan F. Huang
Cells, matrices and engineered environments for vascular and muscle regeneration.
Independent educational guide. Not affiliated with or endorsed by the universities, professors or laboratories described here. This collection reflects the material currently mapped on Socratic Learn.
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Research primer
Cells, Matrices, and Regeneration
6 lessons · ~46 minutes
An independent one-hour primer on vascular biology, extracellular matrix mechanics, biomaterials, tissue engineering, and experimental reasoning, designed around research themes relevant to the Ngan F. Huang Lab.
- 01What does regenerative medicine try to control?
- 02Endothelial cells, angiogenesis, and stem-cell-derived vascular cells
- 03How can a material tell a cell what to do?
- 04Engineering the cellular microenvironment
- 05How does a tissue-engineering experiment produce evidence?
- 06Case study: engineered skeletal muscle in microgravity
Key concepts
Biomaterials and hydrogels
Explain why biomaterials are used in regenerative medicine.
Cellular microenvironment
Explain why the cellular environment matters for tissue regeneration.
Endothelial cells and angiogenesis
Explain the role of endothelial cells in tissue repair.
Engineered muscle as an experimental model
Reconstruct the logic of a tissue-engineering experiment.
Engineered tissue microenvironments
Explain why biomaterials are used in regenerative medicine.
Experimental design in tissue engineering
Identify independent and dependent variables.
Extracellular matrix mechanics
Explain what matrix stiffness means.
iPSC-derived endothelial cells and phenotype
Explain the role of endothelial cells in tissue repair.
Mechanotransduction
Explain what matrix stiffness means.
Molecular and phenotypic readouts
Identify independent and dependent variables.
Multi-omic evidence and scientific interpretation
Reconstruct the logic of a tissue-engineering experiment.
Regenerative medicine as control of cell behavior
Explain why the cellular environment matters for tissue regeneration.
Important papers
2017
Combinatorial Extracellular Matrix Microenvironments for Probing Endothelial Differentiation of Human Pluripotent Stem Cells
Hou et al.
Why this matters: Studies matrix cues for pluripotent-derived endothelial differentiation.
2022
Single-Cell Transcriptomic Census of Endothelial Changes Induced by Matrix Stiffness and the Association with Atherosclerosis
Zamani et al.
Why this matters: Examines stiffness-associated endothelial phenotypes; does not establish a universal mechanism.
DOI: 10.1002/adfm.202203069
2024
Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening
Kim, Ayan, Shayan, Rando and Huang
Why this matters: Compares engineered muscle models under altered gravity with careful model and translation limits.
DOI: 10.1016/j.stemcr.2024.06.010