Ngan F. Huang Lab

2017

Combinatorial Extracellular Matrix Microenvironments for Probing Endothelial Differentiation of Human Pluripotent Stem Cells

Hou et al.

Why this matters: Studies matrix cues for pluripotent-derived endothelial differentiation.

2022

Single-Cell Transcriptomic Census of Endothelial Changes Induced by Matrix Stiffness and the Association with Atherosclerosis

Zamani et al.

Why this matters: Examines stiffness-associated endothelial phenotypes; does not establish a universal mechanism.

DOI: 10.1002/adfm.202203069

2024

Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening

Kim, Ayan, Shayan, Rando and Huang

Why this matters: Compares engineered muscle models under altered gravity with careful model and translation limits.

DOI: 10.1016/j.stemcr.2024.06.010

Introductory

How does matrix stiffness relate to endothelial behavior?

Computational / literature-data study

Extract reported stiffness and endothelial readouts from the cited studies; plot comparisons and document incompatible units.

Background

Mechanobiology, Endothelial cells, Statistics

Data

Open tables and supplementary materials from the primer papers.

Output

Reproducible notebook or evidence table + research poster

Independent educational idea, not offered or supervised by the lab. Use public or synthetic data only; no wet-lab, animal, clinical or human-subject procedures.

Introductory

Simulate vascular supply in an engineered tissue

Computational / literature-data study

Build a simple diffusion model and test how distance and oxygen-consumption assumptions change simulated supply.

Background

Vascular regeneration, Python, Modeling

Data

Synthetic parameter sweeps with explicitly declared assumptions.

Output

Reproducible notebook or evidence table + research poster

Independent educational idea, not offered or supervised by the lab. Use public or synthetic data only; no wet-lab, animal, clinical or human-subject procedures.

Introductory

Compare evidence from microgravity muscle models

Computational / literature-data study

Create a reproducible evidence table separating morphology, gene-expression and protein readouts; record limitations.

Background

Experimental design, Skeletal muscle engineering

Data

Public figures and tables in the cited muscle-on-a-chip study.

Output

Reproducible notebook or evidence table + research poster

Independent educational idea, not offered or supervised by the lab. Use public or synthetic data only; no wet-lab, animal, clinical or human-subject procedures.